NFL MVP favourite Lamar Jackson has thrown for two touchdowns and run for two more as the top-seeded Baltimore pulled away from the visiting Houston for a 34-10 victory in an AFC divisional playoff game.

And Green Bay followed the Texans out of the playoffs as they lost their NFC divisional match at San Francisco in a thriller, 24-21.

The Ravens will host either the Bills or Chiefs in the AFC championship game. Buffalo and Kansas City are set to play Sunday (Monday AEDT) in the other AFC semi-final.

San Francisco will be at home against the winner of Sunday's match between Detroit and Tampa Bay.

Baltimore broke their game open with 24 unanswered points in the second half, finding the end zone on each of their first three possessions after halftime.

Jackson snapped a 10-10 tie with a 15-yard scoring run less than three minutes into the third quarter, capping a 55-yard drive.

He made it 24-10 on the second play of the fourth quarter, rolling right and flipping a 15-yard touchdown pass to Isaiah Likely to finish a 93-yard drive that lasted 7:03.

Jackson sealed the victory with 6:20 left, running eight yards for a TD to complete a march that ate up 7:10. He completed 16 of 22 passes for 152 yards while gaining 100 yards on 11 carries for the game.

"We studied those guys like no tomorrow," Jackson told ESPN. "We had the bye week, but we still stayed locked in and focused. Started off slow first half, but second half, we dialled up and we started connecting."

Texans rookie quarterback CJ Stroud struggled with the Baltimore defence. He hit on 19 of 33 passes for 175 yards and failed to get the Houston attack into the end zone for the second time in as many meetings with the Ravens.

In the NFC, Christian McCaffrey scored his second touchdown on a six-yard run with 1:07 to play as the 49ers mounted their first second-half comeback of the season to beat Green Bay.

After spending all regular season as front-runners, the Niners (13-5) needed to come from behind for a change, and Brock Purdy and McCaffrey did just enough on the last drive to send San Francisco to its third straight NFC championship game.

Purdy went six for seven for 47 yards on the decisive drive, converting a third down to Brandon Aiyuk and then a 17-yarder to Chris Conley.

McCaffrey finished it off with his run on third-and-short and the 49ers' defence held on from there, with Dre Greenlaw intercepting Jordan Love for the second time to seal San Francisco's fifth straight playoff win over Green Bay (10-9).

That last throw across his body was one of the few mistakes by Love, who had given the Packers the lead with two TD passes in the third quarter.

"We're built for those moments," McCaffrey said. "We didn't play well at all but still had a chance at the end. To go out there and execute is a sign of a high character team."