Victor Wembanyama had 27 points, 11 rebounds and seven blocks in his return from a concussion and San Antonio have taken a 3-1 lead in their Western Conference first-round series against Portland with a 114-93 victory.

De'Aaron Fox added 28 points for the Spurs, who will return home for Game 5 on Tuesday night, while Deni Avdija led the hosts with 26.

San Antonio announced about an hour before the game that Wembanyama, the 7-foot-4 Defensive Player of the Year, would start after clearing the league's concussion protocol.

The Spurs trailed the Blazers by 17 points at the half, but the game was knotted at 74 going into the fourth quarter. Fox and Keldon Johnson hit back-to-back three-pointers to put San Antonio up 90-77 with 7:14 left.

Johnson's dunk with 4:31 remaining made it 101-81 for the visitors and all but sealed the win.

Frenchman Wembanyama sustained a concussion in the first half of the Spurs' 106-103 loss on Tuesday and was unavailable Friday night for Game 3. But they rallied in the third quarter and won 120-108 to take the series lead.

Earlier on Sunday (Monday AEST) in Toronto, Scottie Barnes hit the go-ahead free throws in the final minute and finished with 23 points, Brandon Ingram also scored 23 and the Raptors beat Cleveland 93-89, tying their Eastern Conference series at two games apiece.

"Now it's a best of three," Cavaliers guard James Harden said.

RJ Barrett scored 18 points and Collin Murray-Boyles had 15 points and 10 rebounds for the home side, who won despite shooting four for 30 from three-point range.

Barnes had nine rebounds and six assists as Toronto won back-to-back post-season games for the first time since a first-round loss to Philadelphia in 2022.

"We just never, never flinched," Raptors coach Darko Rajakovic said.

Donovan Mitchell scored 12 of his 20 points in the fourth quarter and Harden added 19, but the Cavs couldn't overcome an 18-turnover performance.

Cleveland hosts Game 5 on Wednesday.